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Reduction of flurazepam's antiseizure efficacy persists after stress.

Abstract
Twenty-four hours after mice were forced to swim for up to 10 min in cold (6 degrees C) water, the ability of flurazepam to antagonize the electrical precipitation of seizures was reduced. This stress-induced reduction in flurazepam's antiseizure efficacy persisted for at least 72 h; but was absent 1 week after the single session of swim stress. The data may be relevant to stress-related psychiatric disorders and suggest that the therapeutic efficacy of benzodiazepines may be altered after a severe stress.
AuthorsJ Mastropaolo, C H Park, D O Norris, D A O'Connor, L G Lukacs, S I Deutsch
JournalPharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 42 Issue 4 Pg. 681-4 (Aug 1992) ISSN: 0091-3057 [Print] United States
PMID1513849 (Publication Type: Journal Article)
Chemical References
  • Anticonvulsants
  • Flurazepam
Topics
  • Animals
  • Anticonvulsants (pharmacology)
  • Cold Temperature
  • Electroshock
  • Flurazepam (pharmacology)
  • Male
  • Mice
  • Seizures (physiopathology, prevention & control)
  • Stress, Psychological (physiopathology)
  • Swimming

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