Experimental Albizia versicolor poisoning in sheep and its successful treatment with pyridoxine hydrochloride.

Abstract

Five sheep developed severe nervous signs after being drenched with Albizia versicolor pod-material. Four of these sheep were treated with pyridoxine hydrochloride (a vitamin B6) when the symptoms of toxicity became life-threatening. All the treated sheep recovered dramatically and completely after treatment while the untreated one died 2 h after receiving pod-material. A therapeutic dose of 20-25 mg pyridoxine hydrochloride/kg body mass given twice with an 8 h interval is the recommended treatment regimen. The route of administration will depend on the severity of symptoms. Chemical pathology and post-mortem findings are discussed.

• Authors: B Gummow, S S Bastianello, L Labuschagne, G L Erasmus
• Journal: The Onderstepoort journal of veterinary research (Onderstepoort J Vet Res) Vol. 59 Issue 2 Pg. 111-8 (Jun 1992) ISSN: 0030-2465 [Print] South Africa
• PMID: 1513591 (Publication Type: Journal Article)

Chemical References

• Pyridoxine

Topics

• Animals
• Female
• Pilot Projects
• Plant Poisoning (drug therapy, pathology, veterinary)
• Plants, Toxic
• Pyridoxine (therapeutic use)
• Sheep
• Sheep Diseases (drug therapy, etiology, pathology)