Abstract |
The efficacy of two formulations of abamectin, i.e. oral and injectable was determined against ivermectin-resistant strain of T. colubriformis in sheep. Twenty-four lambs were infected with 10,000 third stage larvae of ivermectin-resistant strain of T. colubriformis. Twenty-four days post- infection, the lambs were divided randomly into four groups of six animals each according to egg counts. The first group was left untreated and kept as a control. The second group was treated with ivermectin (oral) at 0.2mg kg(-1) body weight. The third group was treated with oral formulation of abamectin at 0.2mg kg(-1) body weight. The fourth group was treated with injectable formulation of abamectin at 0.2mg kg(-1) body weight. Fecal egg count and controlled slaughter tests were employed to determine the efficacy of abamectin (oral and injection) against ivermectin-resistant strain of T. colubriformis in sheep. Reduction in arithmetic mean fecal egg counts achieved by ivermectin (oral), abamectin (oral) and abamectin (injection) was 66, 98 and 76%, respectively 10 days after treatment. Ivermectin (oral), abamectin (oral) and abamectin (injection) reduced arithmetic mean worm burden by 63, 97 and 74%, respectively. The findings demonstrated that abamectin oral formulation was more effective than abamectin injection against ivermectin-resistant strain of T. colubriformis in sheep.
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Authors | Alka, R M Gopal, K S Sandhu, P K Sidhu |
Journal | Veterinary parasitology
(Vet Parasitol)
Vol. 121
Issue 3-4
Pg. 277-83
(May 26 2004)
ISSN: 0304-4017 [Print] Netherlands |
PMID | 15135867
(Publication Type: Journal Article)
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Chemical References |
- Anthelmintics
- abamectin
- Ivermectin
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Topics |
- Administration, Oral
- Animals
- Anthelmintics
(administration & dosage)
- Drug Resistance
- Feces
(parasitology)
- Injections, Subcutaneous
(veterinary)
- Intestine, Small
(parasitology)
- Ivermectin
(administration & dosage, analogs & derivatives, pharmacology)
- Parasite Egg Count
(veterinary)
- Random Allocation
- Sheep
- Sheep Diseases
(drug therapy, parasitology)
- Trichostrongylosis
(drug therapy, parasitology, veterinary)
- Trichostrongylus
(growth & development)
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