Comparative studies on the spermatotoxic effects of dinoseb and its structurally related chemicals.

Abstract

Three dinitrophenolic compounds, dinoseb (DNBP; 7.5 mg/kg b.w.), 4,6-dinitro-o-cresol (DNOC; 4, 7.5, 15 mg/kg b.w.), and 2,4-dinitrophenol (DNP; 7.5, 15, 30 mg/kg b.w.) were administered orally to sexually matured Jcl:SD male rats for 5 consecutive days. Half of the males in each group were necropsied at 3 (D3) and 14 (D14) days after the last dosing, respectively, and examined for the effects of dinitrophenols on spermato-/spermiogenesis. DNBP (7.5 mg/kg), DNOC (15 mg/kg), and DNP (30 mg/kg) caused 1, 5, and 0 deaths, respectively, as well as a decreased body weights during the treatment. Although examinations on D3 revealed no treatment-related alterations, DNBP and DNOC resulted in reduced sperm motility and increased incidence of tailless sperm in the cauda epididymis on D14. DNP also caused slightly increased incidence of tailless sperm on D14. These results demonstrate that DNBP, DNOC, and DNP manifest similar spermatotoxic effects at or around a lethal dose in rats.

• Authors: Ken L Takahashi, Hitoshi Hojo, Hiroaki Aoyama, Shoji Teramoto
• Journal: Reproductive toxicology (Elmsford, N.Y.) (Reprod Toxicol) Vol. 18 Issue 4 Pg. 581-8 (Jun 2004) ISSN: 0890-6238 [Print] United States
• PMID: 15135852 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Cresols
• Dinitrocresols
• Dinitrophenols
• Herbicides
• 4,6-dinitro-o-cresol
• 2,4-Dinitrophenol
• dinoseb

Topics

• 2,4-Dinitrophenol (analogs & derivatives, toxicity)
• Animals
• Body Weight (drug effects)
• Cresols (toxicity)
• Dinitrocresols
• Dinitrophenols (toxicity)
• Epididymis (cytology)
• Genitalia, Male (drug effects)
• Herbicides (toxicity)
• Male
• Organ Size (drug effects)
• Rats
• Rats, Sprague-Dawley
• Sperm Count
• Sperm Motility (drug effects)
• Spermatozoa (drug effects, ultrastructure)