| Abstract | OBJECTIVE: To evaluate the effectiveness and safety of mosapride on treatment of functional dyspepsia. METHODS: Randomized controlled clinical trial was conducted and patients suffered from functional dyspepsia were included. 5 mg mosapride was given three times daily for 4 weeks in the treatment group. 10 mg domperidone was given three times daily for 4 weeks as control. Changes on symptom score, gastric empty or new occurring events were included as outcomes. RESULTS: 231 patients suffered from functional dyspepsia were selected by inclusion and exclusion criteria from August 15 to Oct 22, 1999. Of these, 108 (46.8%) were males, versus 123 (53.2%) females and 118 (51.2%) in the treatment group and 113 (48.9%) as controls. 222 (96.1%) patients were followed up. Results showed that the total efficacy rates in early satiety and abdominal distension were 84.5% and 90.1% in mosapride after the 2 weeks of treatment. Mosapride seemed to be more effective in improving symptoms of belching and heartburn than that in controls (P < 0.05). In 4 weeks, the total efficacy in improving symptoms of abdominal distention and belching showed more effective in mosapride than that in controls (P < 0.05). Decrease of symptoms score was more in mosapride than that in controls (P < 0.05). Mosapride was less effective in controls in improving the gastric empty in terms of proportion (46.2% vs. 25.9%, P = 0.020) and range (46.2% vs. 24.0%, P = 0.003). Side effects would include diarrhea, constipation, headache, dizziness, insomnia, skin scare and the like. There was no significant difference between the two groups (9.6% in mosapride vs. 14.0% in controls). CONCLUSION: Mosapride was safe and effective in improving the symptoms and gastric empty of functional dyspepsia. |
| Authors | Shi-yao Chen, Ji-yao Wang, Chou-wen Zhu, Yao-zong Yuan, Bing Zou, Lu Xia, Ji-yong Liu, Hong-wei Xu, Shang-zhong Zhang, Qing Wang, Xiang-jun Xie, Zhi-quan Zhao, Lin Lin, Nai-zhong Hu, Jian-ming Xu
(Affiliation: Zhongshan Hospital, Fudan University, Shanghai 200032, China.)
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| Journal | Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
(Zhonghua Liu Xing Bing Xue Za Zhi)
Vol. 25
Issue 2
Pg. 165-8
(Feb 2004)
ISSN: 0254-6450 China |
| PMID | 15132875
(Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Multicenter Study, Randomized Controlled Trial)
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| Chemical References |
- Benzamides
- Gastrointestinal Agents
- Morpholines
- mosapride
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| Topics |
- Adult
- Benzamides
(adverse effects, therapeutic use)
- Dyspepsia
(drug therapy)
- Female
- Gastrointestinal Agents
(adverse effects, therapeutic use)
- Humans
- Male
- Middle Aged
- Morpholines
(adverse effects, therapeutic use)
- Treatment Outcome
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