Abstract | AIM: METHODS: RESULTS:
Dizocilpine (0.1-0.25 mg.kg-1, i.p.) was shown to dose-dependently inhibit amygdala kindled seizure, shorten the after discharge duration (ADD) and reduce the Racine's stage (P < 0.01). The combination of dizocilpine with phenobarbital, valproate, nicardipine at ineffective dose shortened ADD or reduced Racine's stages (P < 0.01). Dizocilpine (0.1-0.25 mg.kg-1, i.p.) significantly prolonged the latency and reduced the rate of convulsions and death in mice. CONCLUSION:
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Authors | Wei-zhen Zhong, Yong-juan Zhao, Gui-mei Gao, Zhi-hong Yang, Wang Yue |
Journal | Yao xue xue bao = Acta pharmaceutica Sinica
(Yao Xue Xue Bao)
Vol. 39
Issue 2
Pg. 89-92
(Feb 2004)
ISSN: 0513-4870 [Print] China |
PMID | 15127612
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticonvulsants
- Semicarbazides
- carbamylhydrazine
- Valproic Acid
- Dizocilpine Maleate
- Nicardipine
- Phenobarbital
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Topics |
- Amygdala
(drug effects, physiopathology)
- Animals
- Anticonvulsants
(pharmacology, therapeutic use)
- Dizocilpine Maleate
(pharmacology, therapeutic use)
- Electric Stimulation
- Epilepsy
(chemically induced, drug therapy)
- Female
- Kindling, Neurologic
(drug effects)
- Male
- Mice
- Nicardipine
(pharmacology)
- Phenobarbital
(pharmacology)
- Random Allocation
- Rats
- Rats, Wistar
- Semicarbazides
- Valproic Acid
(pharmacology)
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