Abstract | PURPOSE: To investigate the presence of a hypercoagulable state and vascular endothelial dysfunction in patients with ocular Behçet's disease and relate the results to the activity of ocular and systemic involvement. DESIGN: Cross-sectional laboratory and clinical study. METHODS: RESULTS: The mean values of factor VIII, factor XI, vWF ag, vWF risto, ATIII, and fibrinogen were significantly raised compared to healthy population (for all: P <.001). Most striking were factor VIII activity levels above 130% in 79% (19 of 24) of our patients. 67% (16 of 24) had levels of factor VIII above 150%, which correlates with a fivefold increase in risk of thrombosis. Other prothrombogenic factors were negative in all but 2 patients (1 protein C deficiency, 1 factor V Leiden mutation). Endothelial cell activation, measured by vWF activity, revealed elevated levels in 42% (10/24). Complete/incomplete Behçet's disease patients with present or previous macular edema had significantly higher FVIII levels than complete/incomplete Behçet's disease patients who had never shown any signs of macular edema (P =.04). Further correlations between the laboratory results and clinical symptoms were not found. CONCLUSIONS: We found a generalized hypercoagulable state with endothelial cell activation in ocular Behçet's disease, irrespectively of current ocular disease activity.
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Authors | Kiki Probst, Rob Fijnheer, Aniki Rothova |
Journal | American journal of ophthalmology
(Am J Ophthalmol)
Vol. 137
Issue 5
Pg. 850-7
(May 2004)
ISSN: 0002-9394 [Print] United States |
PMID | 15126149
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens
- Protein C
- Protein S
- Von Willebrand antigen
- von Willebrand Factor
- Ristocetin
- Antithrombin III
- Factor VIII
- Fibrinogen
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Topics |
- Activated Protein C Resistance
(blood)
- Adult
- Antigens
(analysis)
- Antithrombin III
(analysis)
- Behcet Syndrome
(blood, complications)
- Cross-Sectional Studies
- Endothelium, Vascular
(pathology)
- Factor VIII
(analysis)
- Female
- Fibrinogen
(analysis)
- Humans
- Male
- Middle Aged
- Prospective Studies
- Protein C
(analysis)
- Protein S
(analysis)
- Ristocetin
(analysis)
- Thrombophilia
(blood, complications)
- Venous Thrombosis
(blood, complications)
- von Willebrand Factor
(immunology)
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