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Transformations of (+-)-salsolinol into optically active O- and/or N-methylated derivatives by several Papaveraceae plants and their tissue-cultured cells.

Abstract
(+-)-Salsolinol [3], a substance possibly inducing parkinsonism, was biotransformed into optically active O- and/or N-methylated salsolinols 5, 6, and 7 by several Papaveraceae plants and tissue-culture cells derived from these plants. The bioconversion of racemic salsolinol into optically active tetrahydroisoquinolines has never been shown to occur, either in animals or in plants.
AuthorsK Iwasa, M Kamigauchi, N Takao
JournalJournal of natural products (J Nat Prod) Vol. 55 Issue 4 Pg. 491-5 (Apr 1992) ISSN: 0163-3864 [Print] United States
PMID1512599 (Publication Type: Journal Article)
Chemical References
  • Isoquinolines
  • salsolinol
Topics
  • Biotransformation
  • Cells, Cultured
  • Chromatography, High Pressure Liquid
  • Culture Techniques
  • Isoquinolines (chemistry, metabolism)
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Plants (metabolism)
  • Stereoisomerism

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