Antitumor agents, 127. Bruceoside C, a new cytotoxic quassinoid glucoside, and related compounds from Brucea javanica.

Abstract

Bruceoside C [5], a new quassinoid glucoside, and related compounds were isolated from Brucea javanica, and their structures were elucidated by spectral data. Bruceoside C showed potent cytotoxicities against KB, A-549, RPMI, and TE-671 tumor cells.

• Authors: N Fukamiya, M Okano, M Miyamoto, K Tagahara, K H Lee
• Journal: Journal of natural products (J Nat Prod) Vol. 55 Issue 4 Pg. 468-75 (Apr 1992) ISSN: 0163-3864 [Print] United States
• PMID: 1512598 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents, Phytogenic
• Quassins
• bruceoside C
• Glaucarubin

Topics

• Animals
• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Drug Screening Assays, Antitumor
• Glaucarubin (analogs & derivatives, chemistry, pharmacology)
• Humans
• Magnetic Resonance Spectroscopy
• Neoplasms (drug therapy, pathology)
• Plants, Medicinal (chemistry)
• Quassins
• Tumor Cells, Cultured