In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent.

Abstract

A new class of dye-based MRI contrast agents, EB-DTPA-Gd, was designed and synthesized. The contrast agent was found to accumulate at the site of endothelial injury when the reagent was applied to isolated porcine blood vessels or in an ex vivo experiment using rat. In vivo MR detection of vascular endothelial injury was also successful in rat with its common carotid artery injured by balloon treatment. These results indicate that EB-DTPA-Gd is potentially useful for the diagnosis of vascular diseases.

• Authors: Tatsuhiro Yamamoto, Kenjiro Ikuta, Keiji Oi, Kohtaro Abe, Toyokazu Uwatoku, Fuminori Hyodo, Masaharu Murata, Noboru Shigetani, Kengo Yoshimitsu, Hiroaki Shimokawa, Hideo Utsumi, Yoshiki Katayama
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 14 Issue 11 Pg. 2787-90 (Jun 07 2004) ISSN: 0960-894X [Print] England
• PMID: 15125933 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Contrast Media
• EB-DTPA-Gd
• Gadolinium DTPA

Topics

• Animals
• Aorta (pathology)
• Carotid Artery Injuries (diagnosis)
• Catheterization (adverse effects)
• Contrast Media (chemistry, pharmacokinetics)
• Disease Models, Animal
• Drug Design
• Endothelium, Vascular (pathology)
• Gadolinium DTPA (analogs & derivatives, pharmacokinetics)
• Magnetic Resonance Imaging (methods)
• Rats
• Swine
• Tissue Distribution
• Vascular Diseases (diagnosis)