Synthesis and anti-inflammatory effect of lipophilic derivatives of threo-DL-phenylserine in rat experimental edema.

Abstract	Novel N- and O-acyl derivatives of threo-DL-phenylserine containing lipophilic long chain carboxylic or aryl(sulfon)amide groups were synthesized. Anti-inflammatory activity in carrageenin-induced paw edema model in rats was studied. Compound 10 had the most expressed anti-inflammatory effect over 24 h.
Authors	N Dirvianskyte, L Leonaviciene, R Bradünaite, V Razumas, E Butkus
Journal	Die Pharmazie (Pharmazie) Vol. 59 Issue 4 Pg. 321-3 (Apr 2004) ISSN: 0031-7144 [Print] Germany
PMID	15125583 (Publication Type: Journal Article)
Chemical References	Anti-Inflammatory Agents, Non-Steroidal Indicators and Reagents Serine Carrageenan
Topics	Animals Anti-Inflammatory Agents, Non-Steroidal (chemical synthesis, pharmacology) Carrageenan Edema (chemically induced, drug therapy, pathology) Foot (pathology) Indicators and Reagents Magnetic Resonance Spectroscopy Male Rats Rats, Wistar Serine (analogs & derivatives, chemical synthesis, pharmacology) Spectrophotometry, Infrared

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