Effects of periodontal dressings on fibroblasts and gingival wound healing in dogs.

Abstract

In the present study the effects of different commercially available periodontal dressings (Peripac, Barricaid, Fittydent, Reso-Pack and Myzotect-tincture) on fibroblast (V-79-379A) proliferation and survival were tested in vitro. Barricaid, Fittydent and Reso-Pack periodontal dressings have only small inhibitory effects on cell proliferation (83.3 +/- 9%, 71.6 +/- 8.7% and 87.3 +/- 4.5% of control after 48 h, respectively) in comparison with the great inhibitory effect of Myzotect-tincture (2.9 +/- 0.1%) and Peripac (33.7 +/- 11.4%) (p < 0.001). Barricaid was the only dressing where 41% of cells survived after exposure, while the other four dressings killed all the cells in 6 days. In addition, the healing of artificially created gingival wounds covered by Barricaid and Reso-Pack was followed for 7 days in 12 Beagle dogs. Histological evaluation of gingival tissue demonstrated that wounds covered by Reso-Pack showed the best epithelisation and vascularity and the least inflammatory reaction in first 4 days. Later the observed parameters were similar with those of wounds covered by Barricaid or without pack. The present results indicate that Peripac periodontal dressing and Myzotect-tincture showed the highest cytotoxicity to fibroblasts in vitro. From the histological observations in Beagle dogs Reso-Pack has been found to be the most suitable dressing, followed by Barricaid.

• Authors: M Petelin, Z Pavlica, Urska Batista, Draga Stiblar-Martincic, U Skaleric
• Journal: Acta veterinaria Hungarica (Acta Vet Hung) Vol. 52 Issue 1 Pg. 33-46 ( 2004) ISSN: 0236-6290 [Print] Hungary
• PMID: 15119785 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adhesives
• Barricaid
• Dental Materials
• Fittydent
• Polyvinyls
• Resins, Synthetic
• Eugenol
• Peripac

Topics

• Adhesives (pharmacology)
• Animals
• Cricetinae
• Dental Materials (pharmacology)
• Dogs (injuries)
• Eugenol (pharmacology)
• Female
• Fibroblasts (drug effects)
• Gingiva (injuries)
• Periodontal Dressings
• Polyvinyls
• Resins, Synthetic (pharmacology)
• Wound Healing
• Wounds, Penetrating (therapy, veterinary)