Abstract | OBJECTIVE: The aims of our study were to determine the basal platelet activation state in women with preeclampsia compared with normotensive pregnant women and nonpregnant women and to investigate the platelet reactivity on in vitro stimulation with adenosine diphosphate or thrombin receptor activation peptide. STUDY DESIGN: RESULTS: Basal platelet expression of CD61, CD42a and CD62P, and adenosine diphosphate-stimulated CD62P expression were increased in women with preeclampsia compared with normotensive pregnant women. Platelets from women with preeclampsia and normotensive pregnant women differed from platelets from nonpregnant women by expressing higher basal CD63 levels and being more responsive to in vitro agonist stimulation, which was demonstrated by increased expression of CD61, CD62P, and CD63. CONCLUSION: This study supports the notion that platelets are important in the pathophysiologic condition of preeclampsia.
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Authors | Mette R Holthe, Anne C Staff, Lillian N Berge, Torstein Lyberg |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 190
Issue 4
Pg. 1128-34
(Apr 2004)
ISSN: 0002-9378 [Print] United States |
PMID | 15118653
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, CD
- CD63 protein, human
- Integrin beta3
- P-Selectin
- Peptide Fragments
- Platelet Glycoprotein GPIb-IX Complex
- Platelet Membrane Glycoproteins
- Tetraspanin 30
- thrombin receptor-activating peptide (P508-530)
- Adenosine Diphosphate
- Protein Phosphatase 2
- DUSP2 protein, human
- Dual Specificity Phosphatase 2
- Protein Tyrosine Phosphatases
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Topics |
- Adenosine Diphosphate
(pharmacology)
- Adult
- Antigens, CD
(metabolism)
- Dual Specificity Phosphatase 2
- Female
- Flow Cytometry
- Humans
- Integrin beta3
(metabolism)
- P-Selectin
(metabolism)
- Peptide Fragments
(pharmacology)
- Platelet Activation
(drug effects)
- Platelet Glycoprotein GPIb-IX Complex
(metabolism)
- Platelet Membrane Glycoproteins
(metabolism)
- Pre-Eclampsia
(blood)
- Pregnancy
(blood)
- Protein Phosphatase 2
- Protein Tyrosine Phosphatases
(metabolism)
- Tetraspanin 30
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