HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Synthesis, properties, and photodynamic properties in vitro of heavy-chalcogen analogues of tetramethylrosamine.

Abstract
Thio and seleno analogues of tetramethylrosamine were prepared by the directed-metalation/cyclization of the corresponding N,N-diethyl 2-(3-dimethylaminophenylchalcogeno)-4-dimethylaminobenzamide to the 2,7-bis-(N,N-dimethylamino)-9H-chalcogenoxanthen-9-one followed by the addition of phenylmagnesium bromide, dehydration, and ion exchange to the chloride salt. The thio and seleno tetramethylrosamines had longer wavelengths of absorption and higher quantum yields for the generation of singlet oxygen than tetramethylrosamine. Both the thio and selenoanalogues of tetramethylrosamine were efficient photosensitizers against R3230AC rat mammary adenocarcinoma cells in vitro.
AuthorsMichael R Detty, Paras N Prasad, David J Donnelly, Tymish Ohulchanskyy, Scott L Gibson, Russell Hilf
JournalBioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 12 Issue 10 Pg. 2537-44 (May 15 2004) ISSN: 0968-0896 [Print] England
PMID15110836 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Chalcogens
  • Heterocyclic Compounds, 3-Ring
  • Photosensitizing Agents
  • Rhodamines
  • Selenium Compounds
  • tetramethylrosamine
  • tetramethylrosamine selenium
  • tetramethylrosamine sulfur
  • Sulfur
  • Selenium
Topics
  • Animals
  • Cell Line, Tumor
  • Cell Survival
  • Chalcogens (chemistry)
  • Heterocyclic Compounds, 3-Ring (chemical synthesis, chemistry, pharmacology)
  • Intracellular Space (ultrastructure)
  • Mass Spectrometry
  • Microscopy, Confocal
  • Molecular Structure
  • Photosensitizing Agents (chemical synthesis, chemistry, pharmacology)
  • Rats
  • Rhodamines
  • Selenium (chemistry)
  • Selenium Compounds (chemical synthesis, chemistry, pharmacology)
  • Sulfur (chemistry)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: