GALOP syndrome: case report with 7-year follow-up.

Abstract

An elderly woman complaining of a gait disorder was found to have the GALOP syndrome (gait ataxia, late-onset polyneuropathy). She exhibited mild distal weakness and sensory loss in the legs, a positive Romberg, and an unsteady gait. Serum immunofixation disclosed a monoclonal IgM-kappa protein. There was specific IgM binding to galopin, a central nervous system white matter antigen. Periodic treatment with intravenous immunoglobulin has alleviated her neurologic symptoms. She has now been followed for 7 years and maintained significant improvement in neurologic symptoms and signs.

• Authors: Jack N Alpert
• Journal: Southern medical journal (South Med J) Vol. 97 Issue 4 Pg. 410-2 (Apr 2004) ISSN: 0038-4348 [Print] United States
• PMID: 15108840 (Publication Type: Case Reports, Journal Article)

Topics

• Age of Onset
• Aged
• Aged, 80 and over
• Female
• Follow-Up Studies
• Gait Ataxia (diagnosis, immunology, therapy)
• Humans
• Polyneuropathies (diagnosis, immunology, therapy)
• Syndrome