HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Associations among human leukocyte antigen (HLA) class II DQ variants, bacterial sexually transmitted diseases, endometritis, and fertility among women with clinical pelvic inflammatory disease.

AbstractBACKGROUND:
We investigated associations between HLA class II DQ alleles, chlamydial and gonococcal cervicitis, endometritis, and infertility among women with pelvic inflammatory disease (PID).
METHODS:
Ninety-two women with clinical signs and symptoms of mild-to-moderate PID, enrolled in the PEACH Study, were evaluated. For all HLA class II DQ alleles with a prevalence of 10% or greater in the population, we assessed demographics, cervical infections, endometrial pathology, and fertility outcomes.
RESULTS:
Chlamydial cervicitis, gonococcal cervicitis, endometritis, and infertility were all more common among women carrying the DQA *0301 allele after adjustment for race. Endometritis and infertility were somewhat less common (or pregnancy more common) among women carrying the DQA *0501 and DQB *0402 alleles.
CONCLUSION:
Among women with signs and symptoms of PID, carriage of the DQA *0301, DQA *0501, and DQB *0402 alleles altered the occurrence of lower genital tract infection, upper genital tract inflammation, and infertility.
AuthorsRoberta B Ness, Robert C Brunham, Caixia Shen, Debra C Bass, PID Evaluation Clinical Health (PEACH) Study Investigators
JournalSexually transmitted diseases (Sex Transm Dis) Vol. 31 Issue 5 Pg. 301-4 (May 2004) ISSN: 0148-5717 [Print] United States
PMID15107633 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • DNA Primers
  • HLA-DQ Antigens
Topics
  • Adolescent
  • Adult
  • Chlamydia Infections (epidemiology)
  • Chlamydia trachomatis
  • DNA Primers
  • Disease Susceptibility
  • Endometritis (epidemiology)
  • Female
  • Gonorrhea (epidemiology)
  • HLA-DQ Antigens (genetics)
  • Humans
  • Infertility, Female (epidemiology)
  • Pelvic Inflammatory Disease (epidemiology, genetics, immunology)
  • Polymerase Chain Reaction
  • United States (epidemiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: