Association between tau polymorphism and male early-onset Alzheimer's disease.

Abstract

Neurofibrillary tangles, containing hyperphosphorylated microtubule-associated protein tau, are one of the major pathological hallmarks of Alzheimer's disease. To investigate a possible association between tau genotypes and the risk of Alzheimer's disease, we screened for polymorphisms in the tau gene and found a novel polymorphism IVS11 + 90G --> A. A case-control study (874 patients and 678 controls) showed a significant association between possession of the A allele and male Alzheimer's disease with early-onset (age of onset before 65, odds ratio = 2.65; 95% confidence interval 1.30-5.42), suggesting that age and gender modify the risk effect. However, we failed to replicate the reported association between the Saitohin gene located in the tau intron 9 and Japanese Alzheimer's disease.

• Authors: Hiroshi Tanahashi, Takashi Asada, Takeshi Tabira
• Journal: Neuroreport (Neuroreport) Vol. 15 Issue 1 Pg. 175-9 (Jan 19 2004) ISSN: 0959-4965 [Print] England
• PMID: 15106853 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• tau Proteins

Topics

• Adult
• Age Factors
• Age of Onset
• Aged
• Aged, 80 and over
• Alzheimer Disease (genetics)
• Amino Acid Sequence (genetics)
• Case-Control Studies
• Female
• Genotype
• Humans
• Male
• Middle Aged
• Molecular Sequence Data
• Polymorphism, Genetic (genetics)
• Sex Factors
• tau Proteins (genetics)