Effects of the Geiji-Bokryung-Hwan on carrageenan-induced inflammation in mice and cyclooxygenase-2 in hepatoma cells of HepG2 and Hep3B.

Abstract

We investigated the effects of a Korean traditional prescription, Geiji-Bokryung-Hwan (GBH) consisting of five herbs of Cinnamomi Ramulus (Korean name Geiji), Poria cocos (Bokryung), Moutan Cortex Radicis (Modanpi). Paeoniae Radix (Jakyak) and Persicae Semen (Doin) on tumor growth-inhibitory activity and cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Effects of the GBH extracts on carrageenan-induced edema inflammation using female (C57BL/6XC3H) F1 (B6C3F1) mice and tumorigenesis were examined. Finally, cyclooxygenase metabolites were determined after extracts treatment. These data suggest that GBH extracts merits investigation as a potential cancer chemopreventive agent in humans.

• Authors: Won-Hwan Park, Shin-Tak Joo, Kwan-Kyu Park, Young-Chae Chang, Cheorl-Ho Kim
• Journal: Immunopharmacology and immunotoxicology (Immunopharmacol Immunotoxicol) Vol. 26 Issue 1 Pg. 103-12 (Feb 2004) ISSN: 0892-3973 [Print] England
• PMID: 15106735 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Geiji-Bokryung-Hwan
• Hydroquinones
• Isoenzymes
• Membrane Proteins
• Plant Extracts
• Tyrphostins
• tyrphostin AG 126
• 9,10-Dimethyl-1,2-benzanthracene
• Carrageenan
• Cyclooxygenase 2
• PTGS2 protein, human
• Prostaglandin-Endoperoxide Synthases
• Protein-Tyrosine Kinases
• Phenylbutazone
• Dinoprostone
• Tetradecanoylphorbol Acetate
• erbstatin
• Indomethacin

Topics

• 9,10-Dimethyl-1,2-benzanthracene (pharmacology)
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
• Carcinoma, Hepatocellular (enzymology, pathology)
• Carrageenan (toxicity)
• Cell Line, Tumor
• Cyclooxygenase 2
• Dinoprostone (metabolism)
• Edema (chemically induced, drug therapy, pathology)
• Female
• Hindlimb (drug effects, pathology)
• Humans
• Hydroquinones (pharmacology)
• Indomethacin (pharmacology)
• Inflammation (chemically induced, drug therapy, pathology)
• Isoenzymes (metabolism)
• Liver Neoplasms (enzymology, pathology)
• Membrane Proteins
• Mice
• Mice, Inbred C57BL
• Mice, Inbred Strains
• Phenylbutazone (pharmacology)
• Plant Extracts (pharmacology, therapeutic use)
• Prostaglandin-Endoperoxide Synthases (metabolism)
• Protein-Tyrosine Kinases (antagonists & inhibitors)
• Skin Neoplasms (chemically induced, pathology, prevention & control)
• Tetradecanoylphorbol Acetate (pharmacology)
• Tyrphostins (pharmacology)