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Infliximab in the treatment of ulcerative colitis with toxic megacolon.

Abstract
Toxic megacolon is a gastrointestinal emergency requiring prompt management to avoid fatal outcome. Although a majority of patients respond to conservative treatment, those not responding have been treated with intravenous cyclosporine or emergency surgery. Infliximab has been tried in patients with severe steroid-refractory ulcerative colitis. We report the successful use of this drug in the management of toxic megacolon in a 48-year-old woman not responding to the routine measures and who refused surgery.
AuthorsParupudi V J Sriram, K S Pavan Reddy, Guduru V Rao, Darisetty Santosh, Duvvuru Nageshwar Reddy
JournalIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology (Indian J Gastroenterol) 2004 Jan-Feb Vol. 23 Issue 1 Pg. 22-3 ISSN: 0254-8860 [Print] India
PMID15106711 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antibodies, Monoclonal
  • Infliximab
Topics
  • Antibodies, Monoclonal (therapeutic use)
  • Colitis, Ulcerative (complications, drug therapy)
  • Humans
  • Infliximab
  • Male
  • Megacolon, Toxic (complications, drug therapy)
  • Middle Aged

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