New prostanoids with cytotoxic activity from Taiwanese octocoral Clavularia viridis.

Abstract

Bioassay-directed fractionation of the CH(2)Cl(2)-MeOH extract of Clavularia viridis collected in Taiwan has afforded seven new prostanoids, designated as 4-deacetoxyl-12-O-deacetylclavulone I (1), 4-deacetoxyl-12-O-deacetylclavulone II (2), bromovulone II (4), iodovulone II (5), 4-deacetoxyl-12-O-deacetylclavulone III (6), bromovulone III (7), and iodovulone III (8), in addition to seven known prostanoids (clavulones I, II, III, 7-acetoxy-7,8-dihydroiodovulone, chlorovulones II, III, and 4-deacetoxylclavulone II (3, claviridenone E)). The structures of compounds 1-8 were determined on the basis of 1D and 2D NMR techniques including COSY, HSQC, and HMBC experiments. Pharmacological study revealed that bromovulone III (7) and chlorovulone II exhibited the most promising cytotoxicity against human prostate (PC-3) and colon (HT29) cancer cells.

• Authors: Ya-Ching Shen, Yuan-Bin Cheng, Yu-Chi Lin, Jih-Hwa Guh, Che-Ming Teng, Chin-Lien Ko
• Journal: Journal of natural products (J Nat Prod) Vol. 67 Issue 4 Pg. 542-6 (Apr 2004) ISSN: 0163-3864 [Print] United States
• PMID: 15104481 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Prostaglandins

Topics

• Animals
• Anthozoa (chemistry)
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Colonic Neoplasms
• Drug Screening Assays, Antitumor
• Humans
• Male
• Molecular Structure
• Nuclear Magnetic Resonance, Biomolecular
• Oceans and Seas
• Prostaglandins (chemistry, isolation & purification, pharmacology)
• Prostatic Neoplasms
• Taiwan
• Tumor Cells, Cultured