| Abstract | Vasopressin is a potent vasopressor for improving organ perfusion during septic shock. The rationale for the use of vasopressin is its relative deficiency of plasma levels and hypersensitivity to its vasopressor effects during septic shock. Growing evidence suggests that low-dose (<0.04 U/min) vasopressin is safe and effective for the treatment of vasodilatory shock. Although it is being used more frequently, there are no randomized clinical trials comparing vasopressin as a first-line agent to commonly used vasopressors. However, vasopressin causes arterial smooth muscle cell contraction through a non-catecholamine receptor pathway, thus it represents an attractive adjunct to the management of septic shock, especially when catecholamines are ineffective. |
| Authors | Gökhan M Mutlu, Phillip Factor
(Affiliation: Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 303 E. Chicago Avenue, Tarry 14-707, Chicago, IL 60611, USA. g-mutlu at northwestern.edu)
|
| Journal | Intensive care medicine
(Intensive Care Med)
Vol. 30
Issue 7
Pg. 1276-91
(Jul 2004)
ISSN: 0342-4642 United States |
| PMID | 15103461
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
|
| Chemical References |
- Vasoconstrictor Agents
- Vasopressins
- terlipressin
- Lysine Vasopressin
|
| Topics |
- Amino Acid Sequence
- Blood Circulation
(drug effects)
- Blood Pressure
(drug effects)
- Dose-Response Relationship, Drug
- Humans
- Lysine Vasopressin
(analogs & derivatives, therapeutic use)
- Models, Biological
- Osmolar Concentration
- Pulmonary Circulation
(drug effects)
- Shock, Septic
(drug therapy)
- Vasoconstrictor Agents
(chemistry, pharmacology, therapeutic use)
- Vasopressins
(chemistry, pharmacology, therapeutic use)
|
