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Anti-inflammatory effect of acute stress on experimental colitis is mediated by cholecystokinin-B receptors.

Abstract
We aimed to investigate the effects of electric shock (ES) on the course of experimental colitis and the involvement of possible central and peripheral mechanisms. In Sprague-Dawley rats (n = 190) colitis was induced by intracolonic administration 2,4,6-trinitrobenzenesulfonic acid (TNBS). The effects of ES (0.3-0.5 mA) or the central administration of corticotropin-releasing factor (CRF; astressin, 10 microg/kg) or cholecystokinin (CCKB; 20 microg/kg) receptor antagonists and peripheral glucocorticoid receptor (RU-486; 10 mg/kg) or ganglion (hexamethonium; 15 mg/kg) blockers on TNBS-induced colitis were studied by the assessment of macroscopic score, histological analysis and tissue myeloperoxidase activity. ES reduced all colonic damage scores (p < 0.05-0.01), while central CRF (p < 0.05-0.001) and CCKB receptor (p < 0.05-0.01) blockers or peripheral hexamethonium (p < 0.05-0.01) and RU-486 (p < 0.05) reversed stress-induced improvement. ES demonstrated an anti-inflammatory effect on colitis, which appears to be mediated by central CRF and CCK receptors with the participation of hypothalamo-pituitary-adrenal axis and the sympathetic nervous system.
AuthorsMehmet Ali Gülpinar, Dilek Ozbeyli, Serap Arbak, Berrak C Yeğen
JournalLife sciences (Life Sci) Vol. 75 Issue 1 Pg. 77-91 (May 21 2004) ISSN: 0024-3205 [Print] Netherlands
PMID15102523 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Ganglionic Blockers
  • Neurotransmitter Agents
  • Receptor, Cholecystokinin B
  • Mifepristone
  • Hexamethonium
  • Trinitrobenzenesulfonic Acid
Topics
  • Acute Disease
  • Animals
  • Colitis (chemically induced, metabolism, pathology)
  • Colon (drug effects, pathology)
  • Disease Models, Animal
  • Electric Stimulation
  • Ganglionic Blockers (administration & dosage, pharmacology)
  • Hexamethonium (administration & dosage, pharmacology)
  • Hypothalamo-Hypophyseal System (metabolism, physiology)
  • Injections, Intraventricular
  • Intestinal Mucosa (drug effects, pathology)
  • Male
  • Mifepristone (administration & dosage, pharmacology)
  • Neurotransmitter Agents (administration & dosage, pharmacology)
  • Pituitary-Adrenal System (metabolism, physiology)
  • Rats
  • Rats, Sprague-Dawley
  • Receptor, Cholecystokinin B (antagonists & inhibitors, metabolism)
  • Restraint, Physical
  • Stress, Physiological (metabolism, physiopathology)
  • Sympathetic Nervous System (metabolism, physiology)
  • Trinitrobenzenesulfonic Acid (toxicity)

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