Mesenteric mast cell degranulation in acute T-2 toxin poisoning.

T-2 toxin-induced alterations in rat mesenteric mast cell granulation were measured by cytophotometric analyses of the metachromatic reaction of mast cell granules with azure B. Hypogranulation (diminution of metachromatic material) was observed 8 h following injections of T-2 toxin (0.5-1.5 LD50, i.p.). These data suggest that mast cell activation occurs during acute T-2 intoxication and raise the possibility that mast cell mediators may contribute to toxin-induced cardiovascular collapse.
AuthorsJ A Doebler, L J Martin, J D Morse, G P Ballough, J A Strauss, A Anthony
JournalToxicology letters (Toxicol Lett) Vol. 62 Issue 1 Pg. 33-8 (Aug 1992) ISSN: 0378-4274 [Print] NETHERLANDS
PMID1509504 (Publication Type: Journal Article)
Chemical References
  • Cations
  • Coloring Agents
  • Heparin
  • T-2 Toxin
  • Animals
  • Cations
  • Cell Degranulation (drug effects)
  • Coloring Agents
  • Cytophotometry
  • Dose-Response Relationship, Drug
  • Heparin (metabolism)
  • Lethal Dose 50
  • Male
  • Mast Cells (drug effects, physiology)
  • Rats
  • Rats, Inbred Strains
  • T-2 Toxin (poisoning, toxicity)
  • Time Factors

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