Abstract | AIM: The aim of the present study was to demonstrate acute, local vasodilatatory effects of insulin and C-peptide on cutaneous microvascular function in Type 1 diabetic subjects. There are no published data available examining physiological effects of C-peptide delivered in this way. METHODS: RESULTS:
C-peptide delivered by iontophoresis produced a vasodilatatory response greater than the response to saline (289.5 +/- 265.9% vs. 105.1 +/- 163.6%, P = 0.003). The response to C-peptide was also shown to be dose dependent. Further, the size of the response to C-peptide correlated well with the size of the response to the endothelium-dependent vasodilatator ACh (r = 0.666, P = 0.001) but not with the size of the response to the endothelium-independent vasodilator SNP (r = 0.345, P > 0.05). CONCLUSIONS: Physiological effects of C-peptide on cutaneous microvascular function could be demonstrated in individuals with Type 1 diabetes. The results support both physiological activity of C-peptide and an endothelium-dependent mechanism similar to that of ACh. The technique reported may be useful in investigating vasoactive actions of C-peptide in a safe and non-invasive way.
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Authors | C Delaney, J Shaw, T Day |
Journal | Diabetic medicine : a journal of the British Diabetic Association
(Diabet Med)
Vol. 21
Issue 5
Pg. 428-33
(May 2004)
ISSN: 0742-3071 [Print] England |
PMID | 15089786
(Publication Type: Journal Article)
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Chemical References |
- C-Peptide
- Hypoglycemic Agents
- Insulin
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Topics |
- Adult
- C-Peptide
(administration & dosage, pharmacology)
- Diabetes Mellitus, Type 1
(physiopathology)
- Dose-Response Relationship, Drug
- Female
- Humans
- Hypoglycemic Agents
(administration & dosage, pharmacology)
- Insulin
(administration & dosage, pharmacology)
- Iontophoresis
- Laser-Doppler Flowmetry
- Male
- Microcirculation
(drug effects)
- Middle Aged
- Pilot Projects
- Skin
(blood supply)
- Vasodilation
(drug effects)
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