Expression of a transcription factor, SOX9, in Sertoli-stromal cell tumors of the ovary.

Abstract

Two cases of ovarian Sertoli-stromal cell tumor were examined for expression of a transcription factor, SOX9, which plays an essential role in Sertoli cell differentiation, downstream of Sry, as in the testis. By reverse transcriptase polymerase chain reaction, SOX9 mRNA was expressed in both tumors, despite the absence of Sry. These findings suggest that SOX9 expression probably plays some role in Sry-independent testicular differentiation in ovarian Sertoli-stromal cell tumors.

• Authors: Noriko Kato, Masayuki Fukase, Teiichi Motoyama
• Journal: International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists (Int J Gynecol Pathol) Vol. 23 Issue 2 Pg. 180-1 (Apr 2004) ISSN: 0277-1691 [Print] United States
• PMID: 15084848 (Publication Type: Journal Article)

Chemical References

• DNA-Binding Proteins
• High Mobility Group Proteins
• Nuclear Proteins
• RNA, Messenger
• SOX9 Transcription Factor
• SOX9 protein, human
• SRY protein, human
• Sex-Determining Region Y Protein
• Transcription Factors

Topics

• Adolescent
• Adult
• DNA-Binding Proteins (biosynthesis)
• Female
• High Mobility Group Proteins (biosynthesis)
• Humans
• Leydig Cell Tumor (metabolism, pathology)
• Male
• Middle Aged
• Nuclear Proteins (biosynthesis)
• Ovarian Neoplasms (metabolism, pathology)
• RNA, Messenger (analysis)
• Reverse Transcriptase Polymerase Chain Reaction
• SOX9 Transcription Factor
• Sertoli Cell Tumor (metabolism, pathology)
• Sex-Determining Region Y Protein
• Transcription Factors (biosynthesis)