Abstract | PURPOSE: MATERIALS AND METHODS: Mice were initially gavaged a lethal dose of sodium fluoride (NaF) or water. Then, mice were treated with water or varying concentrations of calcium chloride (CaCl2) or magnesium sulfate (MgSO4) via intraperitoneal (IP) route or via oral route. Mice were monitored for 24 h, and the time of death was recorded. RESULTS: IP injections of large amounts of CaCl2 or MgSO4 were dangerous. All mice gavaged with water and then treated with oral CaCl2 or MgSO4 survived and displayed normal activity during the experiment. The survival rate of mice gavaged with a lethal dose of NaF and then treated with a high dose of oral CaCl2 or MgSO4 was significantly higher than those of using low dose. CONCLUSION:
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Authors | Wei-Fong Kao, Jou-Fang Deng, Shu-Chiung Chiang, Kennon Heard, David H T Yen, Mei-Chun Lu, Benjamin Ing-Tiau Kuo, Chien-Chun Kuo, Tsung-Yun Liu, Chen-Hsen Lee |
Journal | Journal of toxicology. Clinical toxicology
(J Toxicol Clin Toxicol)
Vol. 42
Issue 1
Pg. 33-40
( 2004)
ISSN: 0731-3810 [Print] United States |
PMID | 15083934
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antidotes
- Magnesium
- Calcium
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Topics |
- Administration, Oral
- Animals
- Antidotes
(administration & dosage, therapeutic use)
- Calcium
(administration & dosage, therapeutic use)
- Dose-Response Relationship, Drug
- Fluoride Poisoning
(drug therapy, mortality)
- In Vitro Techniques
- Injections, Intraperitoneal
- Magnesium
(administration & dosage, therapeutic use)
- Male
- Mice
- Mice, Inbred ICR
- Survival Rate
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