Abstract |
An antibacterial compound active against Streptococcus mutans was isolated from Kaempferia pandurata and identified as isopanduratin A using 1H NMR, 13C NMR and EI-MS. The minimum inhibitory concentration (MIC) of isopanduratin A was 4 mg/l which was much lower than that of some other natural anticariogenic agents such as sanguinarine (12 mg/l), green tea extract and carvacrol (125 mg/l), thymol (250 mg/l) and isoeugenol and eucalyptol (500 mg/l). The bactericidal test showed that isopanduratin A completely inactivated S. mutans at 20 mg/l in 1 min. Significant inhibitory activity of isopanduratin A was also observed against S. sobrinus, S. sanguinis and S. salivarius with an MIC of 4 mg/l. Damage to the cell membrane and cell wall of S. mutans by isopanduratin A was shown using transmission electron microscopy (TEM). These results suggest that isopanduratin A could be employed as a potential antibacterial agent for preventing dental caries.
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Authors | Jae-Kwan Hwang, Jae-Youn Chung, Nam-In Baek, Jung-Hee Park |
Journal | International journal of antimicrobial agents
(Int J Antimicrob Agents)
Vol. 23
Issue 4
Pg. 377-81
(Apr 2004)
ISSN: 0924-8579 [Print] Netherlands |
PMID | 15081087
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Plant Extracts
- isopanduratin A
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Topics |
- Anti-Bacterial Agents
(chemistry, metabolism, pharmacology)
- Cell Membrane
(drug effects)
- Cell Wall
(drug effects)
- Dental Caries
(microbiology)
- Humans
- Microbial Sensitivity Tests
- Microscopy, Electron
- Plant Extracts
(chemistry, metabolism, pharmacology)
- Streptococcus mutans
(drug effects, genetics, ultrastructure)
- Zingiberaceae
(metabolism)
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