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Isopanduratin A from Kaempferia pandurata as an active antibacterial agent against cariogenic Streptococcus mutans.

Abstract
An antibacterial compound active against Streptococcus mutans was isolated from Kaempferia pandurata and identified as isopanduratin A using 1H NMR, 13C NMR and EI-MS. The minimum inhibitory concentration (MIC) of isopanduratin A was 4 mg/l which was much lower than that of some other natural anticariogenic agents such as sanguinarine (12 mg/l), green tea extract and carvacrol (125 mg/l), thymol (250 mg/l) and isoeugenol and eucalyptol (500 mg/l). The bactericidal test showed that isopanduratin A completely inactivated S. mutans at 20 mg/l in 1 min. Significant inhibitory activity of isopanduratin A was also observed against S. sobrinus, S. sanguinis and S. salivarius with an MIC of 4 mg/l. Damage to the cell membrane and cell wall of S. mutans by isopanduratin A was shown using transmission electron microscopy (TEM). These results suggest that isopanduratin A could be employed as a potential antibacterial agent for preventing dental caries.
AuthorsJae-Kwan Hwang, Jae-Youn Chung, Nam-In Baek, Jung-Hee Park
JournalInternational journal of antimicrobial agents (Int J Antimicrob Agents) Vol. 23 Issue 4 Pg. 377-81 (Apr 2004) ISSN: 0924-8579 [Print] Netherlands
PMID15081087 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Bacterial Agents
  • Plant Extracts
  • isopanduratin A
Topics
  • Anti-Bacterial Agents (chemistry, metabolism, pharmacology)
  • Cell Membrane (drug effects)
  • Cell Wall (drug effects)
  • Dental Caries (microbiology)
  • Humans
  • Microbial Sensitivity Tests
  • Microscopy, Electron
  • Plant Extracts (chemistry, metabolism, pharmacology)
  • Streptococcus mutans (drug effects, genetics, ultrastructure)
  • Zingiberaceae (metabolism)

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