[A case of acute poisoning caused by the inhalation of a nonselective herbicide REBIN GT SC (butafenacil and glyphosate isopropylamine)].

Abstract

REBIN GT SC (glyphosate isopropylamine and butafenacil, hereinafter referred to as "REBIN") is a nonselective herbicide which was developed by Syngenta Japan K. K. and was registered in July 2001 as a herbicide. We report the first case of acute poisoning by REBIN. In this case (Age 67, male), high fever and general fatigue developed immediately after REBIN inhalation. Furthermore, urine sugar, urine protein, high LDH and high GPT were observed. But the patient showed a tendency of recovery after the lapse of 48 hours by the intravenous fluid replacement, hydrocortisone sodium succinate (Solu-Cortef), glycyrrhizin (Stronger Neo-Minophagen C) and glutathione (Tathion). He recovered satisfactorily. It is necessary to respect the instructions for the use of REBIN. In addition, in order to prevent inhalation of REBIN, the proper use of instruments and spray at about 30 cm under knee are essential.

• Authors: Motoyuki Ishiguro, Shunsuke Mikasa, Michihiro Otani
• Journal: Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology (Chudoku Kenkyu) Vol. 17 Issue 1 Pg. 51-4 (Jan 2004) ISSN: 0914-3777 [Print] Japan
• PMID: 15079922 (Publication Type: Case Reports, Journal Article)

Chemical References

• Drug Combinations
• Herbicides
• Hydrocarbons, Fluorinated
• Pyrimidines
• glyphosate
• Oleanolic Acid
• neominophagen C
• butafenacil
• Glutathione
• Cysteine
• Glycine
• Hydrocortisone

Topics

• Acute Disease
• Aged
• Cysteine (administration & dosage)
• Drug Combinations
• Fluid Therapy
• Glutathione (administration & dosage)
• Glycine (administration & dosage, analogs & derivatives, poisoning)
• Herbicides (poisoning)
• Humans
• Hydrocarbons, Fluorinated (poisoning)
• Hydrocortisone (administration & dosage)
• Infusions, Intravenous
• Inhalation Exposure (adverse effects)
• Male
• Oleanolic Acid (administration & dosage, analogs & derivatives)
• Pyrimidines (poisoning)
• Treatment Outcome