[Anti-inflammatory effect of arglabin and 11,13-dihydro-13-dimethylaminoarglabin hydrochloride].

Abstract

The sesquiterpene lactone arglabin, as well as its derivative 11,13-Dihydro-13-dimethylaminoarglabin hydrochloride, exhibit antiexudative and antiproliferative properties on the models of acute aseptic inflammation caused by formalin, carrageenan, and histamine, and on the model of proliferative inflammation accompanying cotton-pellet granuloma.

• Authors: A Zh Abil'daeva, R N Pak, A T Kulyiasov, S M Adekenov
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2004 Jan-Feb Vol. 67 Issue 1 Pg. 37-9 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Protivovospalitel'nye svoĭstva arglabina i gidrokhlorida 11,13-digidro-13-dimetilaminoarglabina.
• PMID: 15079907 (Publication Type: Journal Article)

Chemical References

• 11,13-dihydro-13-dimethylaminoarglabin hydrochloride
• Anti-Inflammatory Agents, Non-Steroidal
• Antineoplastic Agents
• Lactones
• Sesquiterpenes
• Sesquiterpenes, Guaiane
• arglabin

Topics

• Acute Disease
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Antineoplastic Agents (therapeutic use)
• Inflammation (drug therapy, etiology)
• Lactones (therapeutic use)
• Male
• Rats
• Sesquiterpenes (therapeutic use)
• Sesquiterpenes, Guaiane