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Comparative serological evaluation of 10 Blastomyces dermatitidis yeast phase lysate antigens from different sources.

Abstract
Yeast phase lysate antigens from 10 isolates of Blastomyces dermatitidis (dog, ERC-2 and T-58; T-27, polar bear; woodpile, ER-3; bat lung, 48938; human, B5929, B5895, B5896, B5931, and CAPP) from different geographical regions, in addition to a Histoplasma capsulatum (G217B) lysate preparation were compared with respect to their reactivity against serum specimens from dogs, rabbits and humans positive for blastomycosis using an indirect enzyme-linked immunosorbent assay. In addition, the lysate antigens were also assayed against histoplasmosis-positive human serum samples to study their cross-reactivity. Variable results were obtained with T-58 and T-27 exhibiting the greatest reactivity. We also noticed that the lysate did not react consistently to serum samples across species with lesser reactivity evidenced when testing dog sera. Finally, T-58 gave the highest cross-reactivity with histoplasmosis-positive sera. The study may prove valuable in the development of antigen candidates for blastomycosis serodiagnosis.
AuthorsR O Abuodeh, E M Chester, G M Scalarone
JournalMycoses (Mycoses) Vol. 47 Issue 3-4 Pg. 143-9 (Apr 2004) ISSN: 0933-7407 [Print] Germany
PMID15078431 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Fungal
  • Antigens, Fungal
  • Immune Sera
Topics
  • Animals
  • Antibodies, Fungal (blood)
  • Antigens, Fungal (immunology)
  • Blastomyces (immunology)
  • Blastomycosis (diagnosis, immunology, microbiology, veterinary)
  • Cross Reactions
  • Dog Diseases (diagnosis, immunology, microbiology)
  • Dogs
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Immune Sera
  • Rabbits
  • Ursidae

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