Abstract | BACKGROUND: METHODS: Twenty-eight rats were randomized into 3 groups to receive L-NAME 5 mg/kg/h, L- canavanine 20 mg/kg/h, and equivalent volume of saline, respectively, i.v. infusion after the induction of pancreatitis for 5 hours. The serum levels of amylase and lipase and mean arterial pressure and heart rate at baseline and 5 hours, and cardiac output, systemic vascular resistance, the amount of ascites and pancreatic histopathology at 5 hours were examined. RESULTS: Five hours after induction of pancreatitis, all rats treated with L- canavanine and all but 1 treated with saline survived; however, all rats treated with L-NAME died. As compared with the control group, L- canavanine significantly reduced serum levels of amylase and lipase, the severity of pancreatic edema and necrosis, and the volume of ascites in 5 hours. In addition, L- canavanine significantly improved the reduction of mean arterial pressure and systemic vascular resistance at 5 hours. CONCLUSIONS:
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Authors | Chun-Chia Chen, Sun-Sang Wang, Shyh-Haw Tsay, Fa-Yauh Lee, Rei-Hwa Lu, Full-Yang Chang, Shou-Dong Lee |
Journal | Journal of the Chinese Medical Association : JCMA
(J Chin Med Assoc)
Vol. 67
Issue 1
Pg. 9-14
(Jan 2004)
ISSN: 1726-4901 [Print] Netherlands |
PMID | 15077884
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Enzyme Inhibitors
- Canavanine
- Taurodeoxycholic Acid
- Nitric Oxide Synthase
- Nitric Oxide Synthase Type II
- Nos2 protein, rat
- NG-Nitroarginine Methyl Ester
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Topics |
- Animals
- Canavanine
(pharmacology)
- Enzyme Inhibitors
(pharmacology, therapeutic use)
- Male
- NG-Nitroarginine Methyl Ester
(pharmacology, therapeutic use)
- Nitric Oxide Synthase
(antagonists & inhibitors)
- Nitric Oxide Synthase Type II
- Pancreatitis, Acute Necrotizing
(chemically induced, drug therapy, physiopathology)
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Taurodeoxycholic Acid
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