Plasma and urine glycolate assays for differentiating the hyperoxaluria syndromes.

Abstract

To differentiate hyperoxaluria syndromes we measured plasma and urine glycolate by a novel high performance liquid chromatographic procedure. Mean glycolate level was 7.9 +/- 2.4 mumol./l. in plasma and 422 +/- 137 mumol./24 hours in urine from 19 control subjects. Renal clearance was about 50% the glomerular filtration rate irrespective of the underlying disease. There was close correlation between glycolate and oxalate in plasma. Plasma glycolate was normal in all but 8 patients who had primary hyperoxaluria 1. Plasma assay detected the disease more efficiently than urine assay. Pyridoxine decreased oxalate biosynthesis in 2 of the 4 patients treated with it and glycolate assay confirmed this behavior. Glycolate excretion was significantly high in 3 of 8 patients of primary hyperoxaluria 1 patients. Idiopathic stone formers had mild increases in glycolate excretion but this was not related with oxalate excretion. Glycolate levels were normal in 5 patients with enteric hyperoxaluria. We conclude that glycolate assay is essential for identifying patients with primary hyperoxaluria 1 and may represent a valuable tool for differentiating hyperoxaluria.

• Authors: M Marangella, M Petrarulo, C Vitale, D Cosseddu, F Linari
• Journal: The Journal of urology (J Urol) Vol. 148 Issue 3 Pt 2 Pg. 986-9 (Sep 1992) ISSN: 0022-5347 [Print] United States
• PMID: 1507356 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Glycolates
• Oxalates
• glycolic acid

Topics

• Adolescent
• Adult
• Child
• Diagnosis, Differential
• Female
• Glycolates (blood, urine)
• Humans
• Hyperoxaluria (blood, diagnosis, urine)
• Male
• Middle Aged
• Oxalates (blood, urine)
• Syndrome