Abstract | PURPOSE: EXPERIMENTAL DESIGN: RESULTS: Moderate or strong immunostaining was observed for ET-1 in 25.4%, for ET(A)R in 43.7%, and for ET(B)R in 22.2% of breast carcinomas. Of all cases, 44.7% showed significant expression of VEGF. MVD varied between different tumor specimens (range, 0-80; median, 17). We observed a statistically significant correlation between MVD and ET expression status with higher MVD in ET-positive tumors. Moreover, expression of VEGF was found more frequently in tumors with overexpression of the ET axis (each P < 0.001). Staining of VEGF was correlated positively with MVD CONCLUSIONS: These results indicate that increased ET-1, ET(A)R, and ET(B)R expression is associated with increased VEGF expression and higher vascularity of breast carcinomas and, thus, could be involved in the regulation of angiogenesis in breast cancer. Our findings provide evidence that the expression pattern of the ET-axis and in particular of ET(A)R may have clinical relevance in future antiangiogenic targeted therapies for breast cancer.
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Authors | Pia Wülfing, Christian Kersting, Joke Tio, Rudolph-Josef Fischer, Christian Wülfing, Christopher Poremba, Raihanatou Diallo, Werner Böcker, Ludwig Kiesel |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 10
Issue 7
Pg. 2393-400
(Apr 01 2004)
ISSN: 1078-0432 [Print] United States |
PMID | 15073116
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Endothelin-1
- Platelet Endothelial Cell Adhesion Molecule-1
- Receptor, Endothelin A
- Receptor, Endothelin B
- Vascular Endothelial Growth Factor A
- Factor VIII
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Topics |
- Breast Neoplasms
(metabolism, pathology)
- Carcinoma
(metabolism)
- Cell Line, Tumor
- Disease Progression
- Endothelin-1
(biosynthesis)
- Factor VIII
(biosynthesis)
- Humans
- Immunohistochemistry
- Microcirculation
- Neoplasm Metastasis
- Neovascularization, Pathologic
- Platelet Endothelial Cell Adhesion Molecule-1
(biosynthesis)
- Receptor, Endothelin A
(biosynthesis)
- Receptor, Endothelin B
(biosynthesis)
- Tissue Distribution
- Vascular Endothelial Growth Factor A
(biosynthesis)
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