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Both corticotropin-releasing factor receptor type 1 and type 2 are involved in stress-induced inhibition of food intake in rats.

AbstractRATIONALE:
Stress-induced inhibition of food intake is reportedly blocked by a selective corticotropin-releasing factor (CRF) type 1 receptor (CRF1) antagonist, suggesting the involvement of CRF1 in the inhibitory mechanism. CRF1 and CRF2 are considered to function in the inhibition of food intake by CRF-related peptides with different time courses.
OBJECTIVES:
This study was designed to clarify whether CRF2 is also involved in stress-induced inhibition of food intake and to examine the relation of CRF1to CRF2 in the inhibitory mechanism.
METHODS:
Antisauvagine-30 (AS-30), a selective CRF2 antagonist, and/or CRA1000, a selective CRF1 antagonist, were pre-administered intracerebroventricularly and intraperitoneally, respectively, to male Wistar rats deprived of food for 24 h before the animals were exposed to a 1-h period of stressors and food intake in 1 h after stress exposure was examined. The effect of both antagonists on locomotor activity was also examined.
RESULTS:
Pre-administration of 5-30 microg of AS-30 attenuated inhibition of food intake induced by restraint, electric footshock or emotional stress using a communication box. CRA1000 also attenuated the restraint-induced inhibition of food intake at doses of 5 and 10 mg/kg body weight. The reversal of restraint-induced inhibition of food intake by co-administration of AS-30 and CRA1000 was not larger than that by AS-30 or CRA1000 alone. Both antagonists did not affect locomotor activity.
CONCLUSIONS:
These results suggest that not only CRF1, but also CRF2, are involved in stress-induced inhibition of food intake, and that both subtypes of CRF receptor function probably in series in 1 h after stress exposure.
AuthorsAzusa Sekino, Hisayuki Ohata, Asuka Mano-Otagiri, Keiko Arai, Tamotsu Shibasaki
JournalPsychopharmacology (Psychopharmacology (Berl)) Vol. 176 Issue 1 Pg. 30-8 (Oct 2004) ISSN: 0033-3158 [Print] Germany
PMID15071721 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • CRF receptor type 2
  • Peptide Fragments
  • Pyridines
  • Pyrimidines
  • Receptors, Corticotropin-Releasing Hormone
  • antisauvagine 30
  • CRA1000
  • CRF receptor type 1
Topics
  • Animals
  • Dose-Response Relationship, Drug
  • Drug Therapy, Combination
  • Eating (drug effects, physiology)
  • Electroshock (adverse effects, methods)
  • Food Deprivation (physiology)
  • Injections, Intraperitoneal
  • Injections, Intraventricular
  • Japan
  • Male
  • Methods
  • Motor Activity (physiology)
  • Peptide Fragments (pharmacology)
  • Pyridines (pharmacology, therapeutic use)
  • Pyrimidines (pharmacology, therapeutic use)
  • Rats
  • Rats, Wistar
  • Receptors, Corticotropin-Releasing Hormone (administration & dosage, antagonists & inhibitors, physiology)
  • Stress, Psychological (physiopathology, prevention & control)
  • Time Factors

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