Anti-inflammatory agents from Sandoricum koetjape Merr.

Abstract

The anti-inflammatory activity of the stem extracts of Sandoricum koetjape was investigated on topical administration using the TPA (tetradecanoylphorbol acetate)-induced mouse ear inflammation model. Bioassay-guided chromatographic fractionation of active fractions led to the isolation 3-oxo-12-oleanen-29-oic acid and katonic acid as the bioactive principles responsible for the anti-inflammatory acitivity. The percentage of inhibition exhibited by 3-oxo-12-oleanen-29-oic acid was almost equivalent to indomethacin.

• Authors: M A Rasadah, S Khozirah, A A Aznie, M M Nik
• Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology (Phytomedicine) Vol. 11 Issue 2-3 Pg. 261-3 (Feb 2004) ISSN: 0944-7113 [Print] Germany
• PMID: 15070182 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• Plant Extracts
• Tetradecanoylphorbol Acetate

Topics

• Animals
• Anti-Inflammatory Agents (administration & dosage, pharmacology, therapeutic use)
• Female
• Inflammation (chemically induced, prevention & control)
• Meliaceae
• Mice
• Mice, Inbred BALB C
• Phytotherapy
• Plant Extracts (administration & dosage, pharmacology, therapeutic use)
• Plant Stems
• Tetradecanoylphorbol Acetate