Association of metabolic gene polymorphisms with tobacco consumption in healthy controls.

Abstract

Polymorphisms in genes that encode for metabolic enzymes have been associated with variations in enzyme activity between individuals. Such variations could be associated with differences in individual exposure to carcinogens that are metabolized by these genes. In this study, we examine the association between polymorphisms in several metabolic genes and the consumption of tobacco in a large sample of healthy individuals. The database of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens was used. All the individuals who were controls from the case-control studies included in the data set with information on smoking habits and on genetic polymorphisms were selected (n = 20938). Sufficient information was available on the following genes that are involved in the metabolism of tobacco smoke constituents: CYP1A1, GSTM1, GSTT1, NAT2 and GSTP1. None of the tested genes was clearly associated with smoking behavior. Information on smoking dose, available for a subset of subjects, showed no effect of metabolic gene polymorphisms on the amount of smoking. No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected.

• Authors: Kim M Smits, Simone Benhamou, Seymour Garte, Matty P Weijenberg, Yannis Alamanos, Christine Ambrosone, Herman Autrup, Judith L Autrup, Helena Baranova, Lisa Bathum, Paolo Boffetta, C Bouchardy, Jurgen Brockmoller, Dorota Butkiewicz, Ingolf Cascorbi, Margie L Clapper, Christiane Coutelle, Ann K Daly, Giacomo Muzi, Vita Dolzan, Tatyana G Duzhak, Katrin Farker, Klaus Golka, Aage Haugen, David W Hein, Allan Hildesheim, Ari Hirvonen, Ling L Hsieh, Magnus Ingelman-Sundberg, Ivan Kalina, Daehee Kang, Takahiko Katoh, Masahiro Kihara, Masako Ono-Kihara, Heon Kim, Chikako Kiyohara, Pierre Kremers, Philip Lazarus, Loic Le Marchand, Maria C Lechner, Stephanie London, Johannes J Manni, Christine M Maugard, Gareth J Morgan, Shunji Morita, Valle Nazar-Stewart, Vessela Nedelcheva Kristensen, Yoshio Oda, Fritz F Parl, Wilbert H M Peters, Agneta Rannug, Timothy Rebbeck, Luis F Ribeiro Pinto, Angela Risch, Marjorie Romkes, Jan Salagovic, Bernadette Schoket, Janeric Seidegard, Peter G Shields, Edith Sim, Daniel Sinnett, Richard C Strange, Isabelle Stucker, Haruhiko Sugimura, Jordi To-Figueras, Paolo Vineis, Mimi C Yu, Wei Zheng, Paola Pedotti, Emanuela Taioli
• Journal: International journal of cancer (Int J Cancer) Vol. 110 Issue 2 Pg. 266-70 (Jun 10 2004) ISSN: 0020-7136 [Print] United States
• PMID: 15069692 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2004 Wiley-Liss, Inc.

Chemical References

• Isoenzymes
• Arylamine N-Acetyltransferase
• NAT2 protein, human
• glutathione S-transferase T1
• GSTP1 protein, human
• Glutathione S-Transferase pi
• Glutathione Transferase
• glutathione S-transferase M1

Topics

• Arylamine N-Acetyltransferase (genetics)
• Genetic Predisposition to Disease
• Glutathione S-Transferase pi
• Glutathione Transferase (genetics)
• Humans
• Isoenzymes (genetics)
• Polymorphism, Genetic
• Smoking (genetics)