Interocular asymmetry of visual field defects in primary open angle glaucoma and primary angle-closure glaucoma.

Abstract

AIM:

To compare the interocular asymmetry in visual field loss of patients with primary open-angle (POAG) and primary angle-closure glaucoma (PACG).

METHODS:

Subjects entering a prospective, randomised, controlled trial of intraoperative 5-fluorouracil in glaucoma surgery in Singapore were included. Preoperative visual field testing was performed using automated white-on-white perimetry (24-2 test pattern, threshold program, Mk II, Model 750, Zeiss-Humphrey, San Leandro, CA, USA). A minimum of two tests were required with mean deviation within 2 dB on two tests, fixation losses <20%, false positives <33%, and false negatives <33%. The second field was scored using AGIS II criteria and the 'mean asymmetry score' defined as the mean difference between eyes for both AGIS scores and global indices.

RESULTS:

In 230 subjects assessed (128 POAG, 102 PACG), mean interocular asymmetry of visual field loss was greater for the PACG group. The mean AGIS asymmetry scores for total (PACG=9.21+/-6.87 vs POAG=6.48+/-5.58, P=0.001), superior (PACG=4.31+/-3.39 vs POAG=3.35+/-3.13, P=0.035), and inferior (PACG=4.43+/-3.31 vs POAG=2.64+/-2.77, P<0.0001) areas and mean deviation (MD) asymmetry scores (PACG=6.89+/-13.22 vs POAG=1.66+/-16.97, P=0.012) were all significantly different. Interocular correlation of visual field loss for POAG was significant; total AGIS, r=0.27 (P=0.003), superior field AGIS, r=0.24 (P=0.008), inferior field AGIS, r=0.34 (P=0.0001), and MD, r=0.27 (P=0.003). In PACG, there was no significant correlation between eyes; total AGIS, r=-0.02 (P=0.85), superior field AGIS, r=-0.02 (P=0.82), inferior field AGIS, r=-0.17 (P=0.87), and MD, r=0.015 (P=0.89).

CONCLUSION:

There was a greater asymmetry of visual field loss between eyes, as measured by AGIS scores and MD, in PACG than that in POAG.

• Authors: J-C Wang, G Gazzard, P J Foster, J G Devereux, F T S Oen, P T K Chew, P T Khaw, S K L Seah
• Journal: Eye (London, England) (Eye (Lond)) Vol. 18 Issue 4 Pg. 365-8 (Apr 2004) ISSN: 0950-222X [Print] England
• PMID: 15069431 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Topics

• Aged
• Female
• Glaucoma, Angle-Closure (complications, physiopathology)
• Glaucoma, Open-Angle (complications, physiopathology)
• Humans
• Male
• Middle Aged
• Prospective Studies
• Vision Disorders (etiology, pathology)
• Visual Field Tests (methods)
• Visual Fields