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Healing of severe ulcerative necrobiosis lipoidica with cyclosporin.

Abstract
A 55-year-old woman with severe, chronic, treatment-resistant ulcerating necrobiosis lipoidica of the shins was commenced on oral cyclosporin at a dose of 2.5 mg/kg/day. Improvement started within 1 week of commencing treatment, and the lesions healed completely over 8 months. Further ulceration occurred 3 months after discontinuing cyclosporin, with improvement on reintroduction of cyclosporin. There have been four previous case reports of healing of treatment-resistant ulcerating necrobiosis lipoidica with cyclosporin.
AuthorsAmy Stanway, Marius Rademaker, Paul Newman
JournalThe Australasian journal of dermatology (Australas J Dermatol) Vol. 45 Issue 2 Pg. 119-22 (May 2004) ISSN: 0004-8380 [Print] Australia
PMID15068460 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Dermatologic Agents
  • Immunosuppressive Agents
  • Cyclosporine
Topics
  • Cyclosporine (therapeutic use)
  • Dermatologic Agents (therapeutic use)
  • Female
  • Follow-Up Studies
  • Humans
  • Immunosuppressive Agents (therapeutic use)
  • Middle Aged
  • Necrobiosis Lipoidica (drug therapy)
  • Recurrence
  • Skin Ulcer (drug therapy)
  • Wound Healing

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