Healing of severe ulcerative necrobiosis lipoidica with cyclosporin.

A 55-year-old woman with severe, chronic, treatment-resistant ulcerating necrobiosis lipoidica of the shins was commenced on oral cyclosporin at a dose of 2.5 mg/kg/day. Improvement started within 1 week of commencing treatment, and the lesions healed completely over 8 months. Further ulceration occurred 3 months after discontinuing cyclosporin, with improvement on reintroduction of cyclosporin. There have been four previous case reports of healing of treatment-resistant ulcerating necrobiosis lipoidica with cyclosporin.
AuthorsAmy Stanway, Marius Rademaker, Paul Newman
JournalThe Australasian journal of dermatology (Australas J Dermatol) Vol. 45 Issue 2 Pg. 119-22 (May 2004) ISSN: 0004-8380 [Print] Australia
PMID15068460 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Dermatologic Agents
  • Immunosuppressive Agents
  • Cyclosporine
  • Cyclosporine (therapeutic use)
  • Dermatologic Agents (therapeutic use)
  • Female
  • Follow-Up Studies
  • Humans
  • Immunosuppressive Agents (therapeutic use)
  • Middle Aged
  • Necrobiosis Lipoidica (drug therapy)
  • Recurrence
  • Skin Ulcer (drug therapy)
  • Wound Healing

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: