Abstract | UNLABELLED: The main objective of this study was to assess in 5-6-year-old French children (n=234) the persistence of antibodies induced by a primary series vaccination (at 2-4 months of age) and a first booster (at 12-16 months of age) with a pentavalent two-component acellular pertussis combined vaccine (DTacP-IPV-Hib; Pentavac). The second objective was to evaluate in these 5-6-year-old French children the safety and the immunogenicity of a tetravalent acellular pertussis combined vaccine (DTacP-IPV; Tetravac) given as second booster. RESULTS: Seroprotective antibody levels against diphtheria, tetanus, types 1-3 poliomyelitis and PRP were maintained 4-5 years after primary-vaccination and first booster with Pentavac. As expected, anti-PT antibodies levels were low, suggesting that children were not colonised by Bordetella pertussis. The second booster with Tetravac was well tolerated and elicited a strong booster response for all antigens. CONCLUSION:
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Authors | Eric Mallet, Noëlle Matisse, Nicolas Mathieu, Jacques Langue, Florence Boisnard, Benoît Soubeyrand, Pentavac Study Group |
Journal | Vaccine
(Vaccine)
Vol. 22
Issue 11-12
Pg. 1415-22
(Mar 29 2004)
ISSN: 0264-410X [Print] Netherlands |
PMID | 15063564
(Publication Type: Clinical Trial, Clinical Trial, Phase III, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Antibodies
- Diphtheria-Tetanus-Pertussis Vaccine
- Haemophilus Vaccines
- Poliovirus Vaccines
- Vaccines, Combined
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Topics |
- Antibodies
(analysis)
- Antibody Formation
(immunology)
- Child
- Child, Preschool
- Diphtheria-Tetanus-Pertussis Vaccine
(adverse effects, immunology)
- Female
- France
(epidemiology)
- Haemophilus Vaccines
(adverse effects, immunology)
- Haemophilus influenzae type b
(immunology)
- Humans
- Immunization, Secondary
- Immunologic Memory
(immunology)
- Male
- Poliovirus Vaccines
(adverse effects, immunology)
- Vaccination
- Vaccines, Combined
(adverse effects, immunology)
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