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Antibody persistence against diphtheria, tetanus, pertussis, poliomyelitis and Haemophilus influenzae type b (Hib) in 5-6-year-old children after primary vaccination and first booster with a pentavalent combined acellular pertussis vaccine: immunogenicity and tolerance of a tetravalent combined acellular pertussis vaccine given as a second booster.

AbstractUNLABELLED:
The main objective of this study was to assess in 5-6-year-old French children (n=234) the persistence of antibodies induced by a primary series vaccination (at 2-4 months of age) and a first booster (at 12-16 months of age) with a pentavalent two-component acellular pertussis combined vaccine (DTacP-IPV-Hib; Pentavac). The second objective was to evaluate in these 5-6-year-old French children the safety and the immunogenicity of a tetravalent acellular pertussis combined vaccine (DTacP-IPV; Tetravac) given as second booster.
RESULTS:
Seroprotective antibody levels against diphtheria, tetanus, types 1-3 poliomyelitis and PRP were maintained 4-5 years after primary-vaccination and first booster with Pentavac. As expected, anti-PT antibodies levels were low, suggesting that children were not colonised by Bordetella pertussis. The second booster with Tetravac was well tolerated and elicited a strong booster response for all antigens.
CONCLUSION:
acellular pertussis combined vaccine, used in primary-vaccination, could be considered as having the same priming effect and the same efficacy as whole cell pertussis vaccine.
AuthorsEric Mallet, Noëlle Matisse, Nicolas Mathieu, Jacques Langue, Florence Boisnard, Benoît Soubeyrand, Pentavac Study Group
JournalVaccine (Vaccine) Vol. 22 Issue 11-12 Pg. 1415-22 (Mar 29 2004) ISSN: 0264-410X [Print] Netherlands
PMID15063564 (Publication Type: Clinical Trial, Clinical Trial, Phase III, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Antibodies
  • Diphtheria-Tetanus-Pertussis Vaccine
  • Haemophilus Vaccines
  • Poliovirus Vaccines
  • Vaccines, Combined
Topics
  • Antibodies (analysis)
  • Antibody Formation (immunology)
  • Child
  • Child, Preschool
  • Diphtheria-Tetanus-Pertussis Vaccine (adverse effects, immunology)
  • Female
  • France (epidemiology)
  • Haemophilus Vaccines (adverse effects, immunology)
  • Haemophilus influenzae type b (immunology)
  • Humans
  • Immunization, Secondary
  • Immunologic Memory (immunology)
  • Male
  • Poliovirus Vaccines (adverse effects, immunology)
  • Vaccination
  • Vaccines, Combined (adverse effects, immunology)

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