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Rescue of interferon induced bone marrow aplasia in a patient with chronic myeloid leukemia by allogeneic bone marrow transplant.

Abstract
A patient with chronic phase Philadelphia chromosome positive CML, developed severe protracted bone marrow hypoplasia after interferon therapy. This complication did not respond to two courses of immunosuppressive therapy with anti-thymocyte globulin, cyclosporin A and prednisone. The patient continued to be transfusion dependent with persistence of Philadelphia chromosome. Allogeneic BMT restored normal hematopoeisis.
AuthorsA Alabdulaaly, J Rifkind, H Solow, H A Messner, J H Lipton
JournalLeukemia & lymphoma (Leuk Lymphoma) Vol. 45 Issue 1 Pg. 175-7 (Jan 2004) ISSN: 1042-8194 [Print] United States
PMID15061216 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Interferon-alpha
Topics
  • Adult
  • Bone Marrow (abnormalities)
  • Bone Marrow Diseases (chemically induced, complications, pathology, surgery)
  • Bone Marrow Transplantation
  • Female
  • Humans
  • Interferon-alpha (adverse effects)
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive (complications, pathology)
  • Transplantation, Homologous

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