Abstract | BACKGROUND: OBJECTIVE: DESIGN: Multicentre randomized double-blind trial. PATIENTS AND SETTING: A total of 397 patients from 14 ICUs of university hospitals in France. INTERVENTION: MEASUREMENTS: RESULTS: Of 367 patients having a successful catheter insertion, 363 were analysed (175 NCC and 188 ACC). Patients had one (NCC=162, ACC=180) or more (NCC=13, ACC=11) CVC inserted. The two groups were similar for insertion site [subclavian (64 vs 69)] or jugular (36 vs 31%)], and type of catheters (single-lumen 18 vs 18%; double-lumen 82 vs 82%), and mean (median) duration of catheterisation [12.0+/-11.7 (9) vs 10.5+/-8.8 (8) days in the NCC and ACC groups, respectively]. Significant colonisation of the catheter occurred in 23 (13.1%) and 7 (3.7%) patients, respectively, in the NCC and ACC groups (11 vs 3.6 per 1000 catheter-days; p=0.01); CVC-related infection (bloodstream infection) occurred in 10 (5) and 4 (3) patients in the NCC and CC groups, respectively (5.2 vs 2 per 1000 catheter days; p=0.10). CONCLUSIONS:
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Authors | Christian Brun-Buisson, Françoise Doyon, Jean-Pierre Sollet, Jean-François Cochard, Yves Cohen, Gérard Nitenberg |
Journal | Intensive care medicine
(Intensive Care Med)
Vol. 30
Issue 5
Pg. 837-43
(May 2004)
ISSN: 0342-4642 [Print] United States |
PMID | 15060765
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Infective Agents, Local
- Chlorhexidine
- Silver Sulfadiazine
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Topics |
- Anti-Infective Agents, Local
(therapeutic use)
- Bacteremia
(etiology, prevention & control)
- Catheterization, Central Venous
(adverse effects)
- Chlorhexidine
(therapeutic use)
- Double-Blind Method
- Equipment Contamination
(prevention & control)
- France
- Humans
- Intensive Care Units
- Middle Aged
- Severity of Illness Index
- Silver Sulfadiazine
(therapeutic use)
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