[Role of adenosine in intraocular pressure].

Abstract

Adenosine is thought to participate in the regulation of intraocular pressure since adenosine and several adenosine derivatives increase and/or decrease intraocular pressure. This article reviews the involvement of adenosine receptors in the regulation of intraocular pressure and the possible application of relatively selective adenosine A(2)-receptor agonists, 2-alkynyladenosine derivatives (2-AAs), as novel drugs for treatment of glaucoma. We found that some 2-AAs decreased intraocular pressure in normotensive rabbits. Moreover, these 2-AAs are also effective in the ocular hypertensive models induced by water-loading and alpha-chymotrypsin. In addition, the ocular hypotension induced by 2-(1-octyn-1-yl) derivative was inhibited by an adenosine A(2)-receptor antagonist 3,7-dimethyl-1-propargylxanthine, but not by an adenosine A(1) receptor antagonist 8-cyclopentyl-1,3-dipropyl xanthine. Moreover, the outflow facility was increased by the 2-(1-octyn-1-yl) derivative. These findings suggest that 2-AAs may affect intraocular pressure via adenosine A(2)-receptor, and 2-AAs-induced ocular hypotension is due to the increase in outflow facility. Some 2-AAs may be novel drugs against ocular hypertension and/or glaucoma, although additional studies are required to characterize the effects of 2-AAs on regulation of intraocular pressure in detail.

• Authors: Takashi Konno
• Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica (Nihon Yakurigaku Zasshi) Vol. 123 Issue 4 Pg. 289-94 (Apr 2004) ISSN: 0015-5691 [Print] Japan
• PMID: 15056945 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Adenosine A2 Receptor Agonists
• Phenethylamines
• Receptors, Adenosine A2
• 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine
• Adenosine

Topics

• Adenosine (analogs & derivatives, pharmacology, physiology, therapeutic use)
• Adenosine A2 Receptor Agonists
• Animals
• Drug Design
• Glaucoma (drug therapy)
• Humans
• Intraocular Pressure (drug effects)
• Ocular Hypertension (drug therapy)
• Phenethylamines (pharmacology, therapeutic use)
• Rabbits
• Receptors, Adenosine A2 (physiology)