HLA-B57 is significantly associated with psoriasis in Northeast Romania [corrected].

Abstract

UNLABELLED:

The aim of the study was to identify HLA class I types associated with susceptibility to psoriasis among population of Northeast region of Romania.

PATIENTS AND METHODS:

27 psoriatic patients and 89 controls were typed serologically for HLA-A and HLA-B lymphocyte expression using CDC-NIH (complement dependent-cytotoxicity--National Institute of Health) method. The Terasaki plates used for HLA class I typing were prepared in our laboratory using antisera of known specificities.

RESULTS AND CONCLUSIONS:

psoriatic patients in the group of study frequently express HLA-B57 phenotype. The relative risk induced by this phenotype was highly statistically significant (p = 0.0016) while HLA-B13 was not associated with a significant risk for developing psoriasis in patients under study compared with controls (p = 0.48). Also, HLA-B27 (p = 0.96) and HLA-B44 (p = 0.99), reported by others to be associated with late psoriasis, do not meet (a particular) disease susceptibility between psoriatic patients under investigation.

• Authors: Venera Vasilca, A Vasilca, Dorina Munteanu, Daniela Constantinescu, Cristina Livideanu, Maria Tepeluş, F Zugun, E Carasevici
• Journal: Roumanian archives of microbiology and immunology (Roum Arch Microbiol Immunol) 2002 Oct-Dec Vol. 61 Issue 4 Pg. 259-65 ISSN: 1222-3891 [Print] Romania
• PMID: 15055259 (Publication Type: Journal Article)

Chemical References

• HLA-B Antigens
• HLA-B57 antigen

Topics

• Adult
• Female
• Genetic Predisposition to Disease (genetics)
• HLA-B Antigens (genetics)
• Histocompatibility Testing
• Humans
• Male
• Middle Aged
• Psoriasis (genetics)
• Romania