[Morphological features of juvenile colon polyps in children].

Abstract

Histological, histochemical and immunohistochemical studies of 50 solitary juvenile polyps (JP) and 50 JP from children with juvenile polyposis syndrome (JPS) were performed. Observations of the focal complex glandular structures with high mitotic rate were more frequent in JP from patients with JPS (n = 29, 58%) than in solitary JP (n = 17, 34%) (p < 0.03). The immunohistochemical study demonstrated p53 overexpression in individual cells and more than 50% of Ki-67-positive cells in 5 (10%) solitary JP and in 17(34%) JP from patients with JPS (p < 0.007). The finding of microglandular pattern is more typical for JP from patients with JPS. Pathological data, expression of p53 and Ki-67 by immunohistochemistry could help to pick out the group of JP with dysplastic changes.

• Authors: A S Tertychnyĭ, D M Konovalov, A G Talalaev
• Journal: Arkhiv patologii (Arkh Patol) Vol. 66 Issue 1 Pg. 28-31 ( 2004) ISSN: 0004-1955 [Print] Russia (Federation)
• Vernacular Title: Morfologicheskie osobennosti iuvenil'nykh polipov tolstoĭ kishki u deteĭ.
• PMID: 15055106 (Publication Type: English Abstract, Journal Article)

Chemical References

• Ki-67 Antigen
• Tumor Suppressor Protein p53

Topics

• Adenomatous Polyposis Coli (genetics, pathology)
• Cell Nucleus (genetics, pathology)
• Cell Transformation, Neoplastic (genetics)
• Child
• Child, Preschool
• Colonic Polyps (genetics, pathology)
• Colonoscopy
• Gene Deletion
• Gene Expression (genetics)
• Humans
• Immunohistochemistry
• Infant
• Ki-67 Antigen (genetics)
• Tumor Suppressor Protein p53 (genetics)