Plasmalemmal vacuolar-type H+-ATPase in cancer biology.

Abstract

Vacuolar-type H+-adenosine triphosphatase (V-ATPase) is one of the most fundamental enzymes in nature. V-ATPases are responsible for the regulation of proton concentration in the intracellular acidic compartments. It has similar structure with the mitochondrial F0F1-ATP synthase (F-ATPase). dagger The V-ATPases are composed of multiple subunits and have various physiological functions, including membrane and organelle protein sorting, neurotransmitter uptake, cellular degradative processes, and cytosolic pH regulation. The V-ATPases have been involved in multidrug resistance. Recently, plasma membrane V-ATPases have been involved in regulation of extracellular acidity, essential for cellular invasiveness and proliferation in tumor metastasis. The current knowledge regarding the structure and function of V-ATPase and its role in cancer biology is discussed.

• Authors: Souad R Sennoune, Defeng Luo, Raul Martínez-Zaguilán
• Journal: Cell biochemistry and biophysics (Cell Biochem Biophys) Vol. 40 Issue 2 Pg. 185-206 ( 2004) ISSN: 1085-9195 [Print] United States
• PMID: 15054222 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)

Chemical References

• Biomarkers, Tumor
• Vacuolar Proton-Translocating ATPases

Topics

• Animals
• Apoptosis
• Biomarkers, Tumor (metabolism)
• Cell Membrane (metabolism)
• Cell Movement
• Humans
• Neoplasm Invasiveness
• Neoplasms (enzymology, pathology)
• Vacuolar Proton-Translocating ATPases (metabolism)