[Potassium canrenoate and the combination of potassium canrenoate-butizide in the therapy of light to moderate arterial hypertension].

Abstract

The aim of the study was to evaluate the antihypertensive effect of K-canrenoate, alone or in combination with butizide, in mild to moderate essential hypertensives. Fifteen patients (supine diastolic blood pressure ranging from 95 to 114 mmHg) received K-canrenoate 50mg/die (step 1). In patients with supine diastolic blood pressure greater than 90 mmHg therapeutic regimen was modified at two-week intervals according to the following design: K-canrenoate 100 mg/die (step 2), K-canrenoate 50 mg + butizide 5 mg/die (step 3), K-canrenoate 100 mg + butizide 10 mg/die (step 4). Blood pressure control was achieved in 2 patients treated with K-canrenoate alone (step 2) and in 8 patients on a combined regimen (step 3), and it was maintained throughout the whole trial period (12 weeks); step 4 did not achieve the goal of therapy in the remaining 5 subjects. A statistically significant increase in triglyceridemia (123.2 +/- 42.1 vs 158.3 +/- 62 mg/dl) and uricemia (4.6 +/- 0.9 vs 5 +/- 0.9 mg/dl) was observed at the end of the follow-up period. Serum potassium levels remained stable in all patients. Therefore, K-canrenoate in combination with butizide is an effective and well tolerated drug in the treatment of mild to moderate essential hypertension.

• Authors: S Morabito, M Fabiano, M Puliti, R Palumbo, R Marinelli, B M Simonetti, A Pierucci
• Journal: La Clinica terapeutica (Clin Ter) Vol. 141 Issue 7 Pg. 23-8 (Jul 1992) ISSN: 0009-9074 [Print] Italy
• Vernacular Title: Il canrenoato di potassio e l'associazione canrenoato di potassio-butizide nella terapia dell'ipertensione arteriosa di grado lieve-moderato.
• PMID: 1505173 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antihypertensive Agents
• Diuretics
• Sodium Chloride Symporter Inhibitors
• Hydrochlorothiazide
• Canrenoic Acid
• buthiazide

Topics

• Adult
• Antihypertensive Agents (adverse effects, therapeutic use)
• Blood Pressure (drug effects)
• Canrenoic Acid (adverse effects, therapeutic use)
• Diuretics
• Drug Evaluation
• Drug Therapy, Combination
• Drug Tolerance
• Female
• Humans
• Hydrochlorothiazide (adverse effects, analogs & derivatives, therapeutic use)
• Hypertension (blood, drug therapy, physiopathology)
• Male
• Middle Aged
• Sodium Chloride Symporter Inhibitors (adverse effects, therapeutic use)