Effect of oral L-arginine on blood pressure and symptoms and endothelial function in patients with systemic hypertension, positive exercise tests, and normal coronary arteries.

Abstract

Thirteen hypertensive patients with microvascular angina were studied before and after receiving oral L-arginine (4 weeks, 2 g, 3 times daily). L-arginine significantly improved angina class, systolic blood pressure at rest, and quality of life. Maximal forearm blood flow, plasma L-arginine, L-arginine:asymmetric dimethyl arginine ratio, and cyclic guanylate monophosphate increased significantly after treatment. In medically treated hypertensive patients with micro-vascular angina, oral L-arginine may represent a useful therapeutic option.

• Authors: Altin Palloshi, Gabriele Fragasso, PierMarco Piatti, Lucilla D Monti, Emanuela Setola, Giampiero Valsecchi, Elena Galluccio, Sergio L Chierchia, Alberto Margonato
• Journal: The American journal of cardiology (Am J Cardiol) Vol. 93 Issue 7 Pg. 933-5 (Apr 01 2004) ISSN: 0002-9149 [Print] United States
• PMID: 15050504 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Arginine

Topics

• Administration, Oral
• Aged
• Arginine (administration & dosage)
• Blood Pressure (drug effects, physiology)
• Endothelium, Vascular (drug effects, physiopathology)
• Female
• Humans
• Hypertension (complications, drug therapy, physiopathology)
• Male
• Microvascular Angina (complications, drug therapy, physiopathology)
• Middle Aged