Dual-mesh optical tomography reconstruction method with a depth correction that uses a priori ultrasound information.

Abstract

A dual-mesh reconstruction method with a depth correction for near-infrared diffused wave imaging with ultrasound localization is demonstrated by use of phantoms and clinical cancer cases. Column normalization is applied to the weight matrix obtained from the Born approximation to correct the depth-dependent problem in the reconstructed absorption maps as well as in the total hemoglobin concentration maps. With the depth correction, more uniform absorption maps for target layers at different depths are obtained from the phantoms, and the correlation between the reconstructed hemoglobin concentration maps of deeply located, large cancers and the histological microvessel density counts are dramatically improved.

• Authors: Minming Huang, Quing Zhu
• Journal: Applied optics (Appl Opt) Vol. 43 Issue 8 Pg. 1654-62 (Mar 10 2004) ISSN: 1559-128X [Print] United States
• PMID: 15046168 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Topics

• Adult
• Breast Neoplasms (diagnosis)
• Carcinoma, Intraductal, Noninfiltrating (diagnosis)
• Female
• Humans
• Image Processing, Computer-Assisted (methods)
• Middle Aged
• Models, Theoretical
• Neoplasm Invasiveness (diagnosis)
• Phantoms, Imaging
• Pregnancy
• Pregnancy Complications, Neoplastic (diagnosis)
• Scattering, Radiation
• Spectroscopy, Near-Infrared
• Tomography, Optical
• Ultrasonography