[Delayed onset of malignant hyperthermia crisis during a living donor liver transplantation caused by sevoflurane].
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| Abstract |
We report on a 25-year old ASA physical status I patient, who developed within 20 minutes a full-blown malignant hyperthermia (MH) in the context of a living donor liver transplantation after 180 minutes of uneventful anaesthesia. The only trigger substance applied was Sevoflurane. The patient had already received a short, uneventful anaesthesia with Isoflurane a couple of years ago. In the context of the special constellation an initial dose of Dantrolene of 10 mg/kg body weight was administered. The patient was stabilised within 30 minutes, and the enzyme levels remained low compared with other case reports. The post-operative in vitro caffeine halothane contracture testing confirmed that son and mother were susceptible to MH, contracture testing in the father was negative. All known triggers may cause life-threatening MH crisis - even after hours and after inconspicuous multiple exposures to known trigger substances. Therefore all trigger substances must be avoided in all patients susceptible to MH.
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| Authors | I Gillmeister, C Schummer, M Hommann, W Schummer |
| Journal | Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS (Anasthesiol Intensivmed Notfallmed Schmerzther) Vol. 39 Issue 3 Pg. 153-6 (Mar 2004) ISSN: 0939-2661 [Print] Germany |
| Vernacular Title | Verzögertes Einsetzen einer Malignen Hyperthermie während einer Leberlebendspende unter Sevoflurananästhesie. |
| PMID | 15042505 (Publication Type: Case Reports, Journal Article) |
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