[Synthesis and immunostimulating activity of cysteine-containing glycopeptide derivatives of glycyrrhizic acid].

Abstract

New cysteine-containing derivatives of glycyrrhizic acid were synthesized by its coupling with Cys(Bzl) esters or the Cys(Bzl)-Val-OBu(t) dipeptide by the active ester method (DCC/HOSu) or by Woodward's reagent K. The derivatives with Cys(Bzl) and Cys(Bzl)-Val residues attached to the carbohydrate part of the molecule stimulated the primary immune response and the reaction of delayed-type hypersensitivity in mice at a dose of 2 mg/kg. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 1; see also http://www.maik.ru.

• Authors: R M Kondratenko, L A Baltina, E V Vasil'eva, L A Baltina, A F Ismagilova, Kh M Nasyrov, N Zh Baschenko, R M Kireeva, S M Fridman, G A Tolstikov
• Journal: Bioorganicheskaia khimiia (Bioorg Khim) 2004 Jan-Feb Vol. 30 Issue 1 Pg. 61-7 ISSN: 0132-3423 [Print] Russia (Federation)
• Vernacular Title: Sintez i immunostimuliruiushchaia aktivnost' tsisteinsoderzhashchikh glikopeptidnykh proizvodnykh glitsirrizinovoĭ kisloty.
• PMID: 15040305 (Publication Type: English Abstract, Journal Article)

Chemical References

• Adjuvants, Immunologic
• Glycopeptides
• Glycyrrhizic Acid
• Cysteine

Topics

• Adjuvants, Immunologic (chemical synthesis, chemistry, pharmacology)
• Cysteine (chemistry)
• Glycopeptides (chemical synthesis, chemistry, pharmacology)
• Glycyrrhizic Acid (chemistry)
• Nuclear Magnetic Resonance, Biomolecular